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Lisinopril

Cat. No. M5747
Lisinopril Structure
Size Price Availability Quantity
50mg USD 68  USD68 In stock
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Quality Control & Documentation
Biological Activity

Lisinopril is an angiotensin converting enzyme inhibitor that has been studied for hypertension, congestive heart failure and heart disease.

Chemical Information
Molecular Weight 405.49
Formula C21H31N3O5
CAS Number 76547-98-3
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Agarwal R, et al. Nephrol Dial Transplant. Hypertension in hemodialysis patients treated with atenolol or lisinopril: a randomized controlled trial.

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