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Lisinopril dihydrate

Cat. No. M5748

Lisinopril dihydrate Structure
Size Price Availability Quantity
1g USD 115 In stock
5g USD 220 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Lisinopril Dihydrate is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 441.52
Formula C21H35N3O7
CAS Number 83915-83-7
Purity >99%
Solubility 4.4 mg/mL in DMSO
Storage at -20°C
References

Lisinopril dihydrate: single-crystal x-ray structure and physicochemical characterization of derived solid forms.
Sorrenti M, et al. J Pharm Sci. 2013 Oct;102(10):3596-603. PMID: 23873413.

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  Catalog
Abmole Inhibitor Catalog 2017




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