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Liproxstatin-1

Cat. No. M8531
Liproxstatin-1 Structure
Synonym:

Lip-1

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 90  USD90 In stock
10mg USD 165  USD165 In stock
25mg USD 390  USD390 In stock
50mg USD 600  USD600 In stock
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Quality Control
Biological Activity

Liproxstatin-1 is a potent inhibitor of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lethal lipid reactive oxygen species (ROS). Liproxstatin-1 suppressed ferroptosis in human cells and in an ischaemia/reperfusion-induced tissue injury model in mice. Knockout of glutathione peroxidase 4 (Gpx4) Has been shown to cause cell death by ferroptosis. Liproxstatin-1 was able to suppress ferroptosis in Gpx4 knock-out mice.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 340.85
Formula C19H21ClN4
CAS Number 950455-15-9
Purity 99.83%
Solubility DMSO ≥ 10 mg/mL
Storage at -20°C
References

[1] Omkar Zilka, et al. On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

[2] Bao-You Fan, et al. Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4

[3] Zhiwei Zheng, et al. Liproxstatin-1 Protects Hair Cell-Like HEI-OC1 Cells and Cochlear Hair Cells against Neomycin Ototoxicity

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Keywords: Liproxstatin-1, Lip-1 supplier, Ferroptosis, inhibitors

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