Lipoic acid is a class of compounds belonging to the B class vitamins and is the growth factor of yeast and some kinds of microorganisms. Lipoic acid can be used for the prevention and treatment of acute hepatitis, liver cirrhosis, hepatic coma, fatty liver and other diseases.
| Molecular Weight | 206.33 |
| Formula | C8H14O2S2 |
| CAS Number | 62-46-4 |
| Solubility (25°C) | Soluble in DMF |
| Storage | 2-8°C, dry, protect from light, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Wei Liu, et al. The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases
[2] Ashley Solmonson, et al. Lipoic acid metabolism and mitochondrial redox regulation
[4] Nikolaos Papanas, et al. Efficacy of α-lipoic acid in diabetic neuropathy
[5] L Packer, et al. alpha-Lipoic acid as a biological antioxidant
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