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Linzagolix

Cat. No. M10477
Linzagolix Structure
Synonym:

KLH-2109; OBE-2109

Size Price Availability Quantity
5mg USD 280  USD280 In stock
10mg USD 390  USD390 In stock
25mg USD 680  USD680 In stock
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Quality Control & Documentation
Biological Activity

Linzagolix is a novel potent, orally active gonadotropin-releasing hormone (GnRH) antagonist.

Chemical Information
Molecular Weight 508.42
Formula C22H15F3N2O7S
CAS Number 935283-04-8
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Susan Dababou, et al. Expert Opin Investig Dгυgs. Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas

[2] Olivier Donnez, et al. Fertil Steril. Gonadotropin-releasing hormone antagonist (linzagolix): a new therapy for uterine adenomyosis

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Keywords: Linzagolix, KLH-2109; OBE-2109 supplier, LHRH/GnRH, inhibitors, activators


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