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Linagliptin

Cat. No. M2814

Linagliptin Structure

Synonym: BI-1356

Size Price Availability Quantity
5mg USD 70 In stock
10mg USD 110 In stock
100mg USD 300 In stock
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Quality Control
Biological Activity

Linagliptin is a highly potent, selective DPP-4 inhibitor with IC50 of 1 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 472.54
Formula C25H28N8O2
CAS Number 668270-12-0
Purity 99.66%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Linagliptin, BI-1356 supplier, DPP-4, inhibitors

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