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Licochalcone D

Cat. No. M9645
Licochalcone D Structure
Size Price Availability Quantity
1mg USD 160  USD160 In stock
5mg USD 480  USD480 In stock
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Quality Control & Documentation
Biological Activity

Licochalcone D is a potent inhibitor of NF-kappaB (NF-κB) p65 with antioxidant, anti-inflammatory, anti-cancer properties. Licochalcone D is a flavonoid compound mainly existing in the root of Glycyrrhiza inflate.

Chemical Information
Molecular Weight 354.40
Formula C21H22O5
CAS Number 144506-15-0
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lingling Si, et al. Oncol Rep. Licochalcone D induces apoptosis and inhibits migration and invasion in human melanoma A375 cells

[2] Jun-ichi Furusawa, et al. Int Immunopharmacol. Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway

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Keywords: Licochalcone D supplier, NF-κB, inhibitors, activators


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