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Levomefolate calcium

Cat. No. M6108
Levomefolate calcium  Structure
Size Price Availability Quantity
5mg USD 90 In stock
10mg USD 150 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 497.52
Formula C20H23CaN7O6
CAS Number 151533-22-1
Purity >99%
Solubility 4.4 mg/mL in water
Storage at -20°C
References

EE-drospirenone-levomefolate calcium versus EE-drospirenone + folic acid: folate status during 24 weeks of treatment and over 20 weeks following treatment cessation.
Diefenbach K, et al. Int J Womens Health. 2013 Apr 11;5:149-63. PMID: 23610531.

The combined oral contraceptive pill containing drospirenone and ethinyl estradiol plus levomefolate calcium.
Rapkin RB, et al. Expert Opin Pharmacother. 2011 Oct;12(15):2403-10. PMID: 21877996.

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