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Levofloxacin hydrate

Cat. No. M5737

Levofloxacin hydrate Structure

Synonym: Levofloxacin hemihydrate, Levaquin hydrate

Size Price Availability Quantity
1g USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. It acts by inhibiting DNA gyrase (bacterial topoisomerase II).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 370.38
Formula C18H20FN3O4.1/2H2O
CAS Number 138199-71-0
Purity >99%
Solubility 74 mg/mL in DMSO
Storage at -20°C
References

Contact urticaria syndrome from eye drops: levofloxacin hydrate ophthalmic solution.
Saito M, et al. J Dermatol. 2013 Feb;40(2):130-1. PMID: 23110602.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Levofloxacin hydrate, Levofloxacin hemihydrate, Levaquin hydrate supplier, Topoisomerase, inhibitors

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