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Levodropropizine

Cat. No. M2811
Levodropropizine Structure
Synonym:

(S)-(-)-Dropropizine

Size Price Availability Quantity
50mg USD 68  USD68 In stock
100mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Levodropropizine possess anti-allergic and inhibits histamine receptor, reduces cough by interfering with stimulus activation of peripheral endings of sensory nerves and by modulation of neuropeptides involved in the cough reflex.

Chemical Information
Molecular Weight 236.31
Formula C13H20N2O2
CAS Number 99291-25-5
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] G Ciprandi, et al. Levodropropizine in children: over thirty years of clinical experience

[2] Anna Karolina Mouzer da Silva Machado, et al. Characteristics, Properties and Analytical Methods for Determination of Dropropizine and Levodropropizine: A Review

[3] Surinder Birring, et al. Antitussive therapy: A role for levodropropizine

[4] Francesco De Blasio, et al. Efficacy of levodropropizine in pediatric cough

[5] Eva Katharina Schildmann, et al. Levodropropizine in the management of cough associated with cancer or nonmalignant chronic disease--a systematic review

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Keywords: Levodropropizine, (S)-(-)-Dropropizine supplier, Histamine Receptor, inhibitors, activators


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