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Levamlodipine

Cat. No. M20409
Levamlodipine Structure
Synonym:

S-amlodipine

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Biological Activity

Levamlodipine is a pharmacologically active enantiomer of amlodipine which belongs to the dihydropyridine group of calcium channel blocker. It acts on the L-type of calcium channels and its treatment results in vasodilation and a fall in blood pressure.

Chemical Information
Molecular Weight 408.88
Formula C20H25ClN2O5
CAS Number 103129-82-4
Solubility (25°C) DMSO 81 mg/mL
Water 81 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Guo-Yao Dai, et al. Medicine (Baltimore). Clinical assessment of levamlodipine besylate combination therapy for essential hypertension: A protocol for systematic review and meta-analysis

[2] Xin Li, et al. BMC Pharmacol Toxicol. Bioequivalence of levamlodipine besylate tablets in healthy Chinese subjects: a single-dose and two-period crossover randomized study

[3] Zhaoqing Liu, et al. Spectrochim Acta A Mol Biomol Spectrosc. Investigation of the binding properties between levamlodipine and HSA based on MCR-ALS and computer modeling

[4] Kai-Xin Yao, et al. Sci Rep. Effect of low-dose Levamlodipine Besylate in the treatment of vascular dementia

[5] Linlin Xu, et al. Spectrochim Acta A Mol Biomol Spectrosc. Probing the interaction between levamlodipine and hemoglobin based on spectroscopic and molecular docking methods

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  Catalog
Abmole Inhibitor Catalog




Keywords: Levamlodipine, S-amlodipine supplier, Calcium Channel, inhibitors, activators


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