Letrozole is an orally active, potent, selective, nonsteroidal, third-generation aromatase (CYP19A1) inhibitor, a synthetic benzyltriazole derivative, which is used in the construction of animal models of polycystic ovary syndrome (PCOS), as well as in studies related to postoperative hormone-responsive breast cancer.
EMBO Mol Med. 2023 Dec.
MYSM1 acts as a novel co-activator of ERα to confer antiestrogen resistance in breast cancer
Letrozole purchased from AbMole
J Steroid Biochem Mol Biol. 2013 Nov;138:54-62.
Effect of androgens on different breast cancer cells co-cultured with or without breast adipose fibroblasts
Letrozole purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | Human breast cancer cells MCF-7 |
| Preparation method | Seeding cells in duplicate at 5,000 to 10,000 cells per well in 24-well plates. The day after plating,adding different concentrations of Letrozole . At the end of incubation, trypsinizating cells and placing in Isotone solution and counting immediately using a Coulter particle-counter. |
| Concentrations | ~100 nM |
| Incubation time | 1 days |
| Animal Experiment | |
|---|---|
| Animal models | Human breast carcinoma xenografts MCF-7 with human aromatase gene (MCF-7Ca) |
| Formulation | 0.5% (w/v) solution of carboxymethylcellulos |
| Dosages | 20 mg/kg/day |
| Administration | orally administered by gavage once every 2 days |
| Molecular Weight | 285.30 |
| Formula | C17H11N5 |
| CAS Number | 112809-51-5 |
| Solubility (25°C) | DMSO ≥ 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Animal Modeling Products |
|---|
| Astragalus Polysacharin (70%)
Astragalus Polysacharin is a natural product from Astragalus membranaeus, used as adjuvant, attenuates TNF-α-induced insulin resistance by suppressing miR-721 and activating PPAR-γ and PI3K/Akt in 3T3-L1 adipocytes. |
| Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin. |
| PLP (139-151)
PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE). |
| G6PI 325-339 (human)
G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice. |
| Heparin sodium salt (MW 15kDa)
Heparin sodium salt (MW 15kDa) is a heparin polymer with a molecular weight of 15kDa.Heparin sodium salt is an anticoagulant that reversibly binds to antithrombin III (ATIII), thereby accelerating the rate of inactivation of Thrombin factor IIa and factor Xa by ATIII. Heparin sodium salt is used for blood collection and plasma preparation in experimental animals and for the construction of parenteral nutrition models in mice. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
