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Leptin (116-130) mouse

Cat. No. M9567
Leptin (116-130) mouse Structure
Synonym:

LEP(116-130) mouse

Size Price Availability Quantity
10mg USD 417  USD417 In stock
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Quality Control & Documentation
Biological Activity

Leptin (116-130) mouse is a synthetic leptin peptide fragment. Leptin (116-130) (1 mg, i.p.) results in a reduced rate of body weight gain in the presence of increased food intake compared with vehicle-injcted control mice. Leptin (116-130) significantly reduces blood glucose levels by appr 100 mg/dL. Administration of Leptin (116-130) to wild-type (+/+) C57BLKS/J-m mice for 4 or 7 days has no effect on their ability to thermoregulate.

Chemical Information
Molecular Weight 1560.73
Formula C64H109N19O24S
CAS Number 258276-95-8
Solubility (25°C) Water ≥ 50 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] P Grasso, et al. Diabetes. Inhibitory Effects of Leptin-Related Synthetic Peptide 116-130 on Food Intake and Body Weight Gain in Female C57BL/6J ob/ob Mice May Not Be Mediated by Peptide Activation of the Long Isoform of the Leptin Receptor

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