Lentinan is purified β-glucan from Shiitake mushrooms, also used as adjuvant. Lentinan is used as an immune regulator and to treat bacterial and viral infections and cancer. Lentinus is currently approved, in combination with the cytostatic tegafur, for the treatment of gastric cancer.
| Formula | (C42H70O35)n |
| CAS Number | 37339-90-5 |
| Solubility (25°C) | Soluble in alkali solution or formic acid |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Kenji Ina, et al. Anticancer Agents Med Chem. The use of lentinan for treating gastric cancer
| Related Adjuvants Products |
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| Schizophyllan
Schizophyllan, a β-D-glucan derived from Schizophyllan, activates Tc cells, NK cells, macrophages, as well as promotes the secretion of various lymphokines such as IL-1, IL-2, IL-3, IFN. It can be used as an immune adjuvant with potential immunomodulatory and antitumor activities. |
| Aluminum Phosphate
Aluminum Phosphate is a widely used adjuvant and has been shown to increase the excretion rate of strontium for use in studies related to vaccines and gastrointestinal diseases. |
| Peptidoglycan
The peptidoglycan (murein) sacculus is a unique and essential structural element in the cell wall of most bacteria. This product is extracted from Bacillus subtilis. |
| QS-21
QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18. |
| Polygalasaponin XXXI
Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine. |
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