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LEI-401

Cat. No. M14511
LEI-401 Structure
Size Price Availability
5mg USD 150  USD150 1-2 Weeks
10mg USD 220  USD220 1-2 Weeks
25mg USD 450  USD450 1-2 Weeks
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Quality Control & Documentation
Biological Activity

LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM.

Chemical Information
Molecular Weight 421.54
CAS Number 2393840-15-6
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Elliot D Mock, et al. Structure-Activity Relationship Studies of Pyrimidine-4-Carboxamides as Inhibitors of N-Acylphosphatidylethanolamine Phospholipase D

[2] Elliot D Mock, et al. Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

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Keywords: LEI-401 supplier, Phospholipase, inhibitors, activators


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