LDN-57444 is a reversible, competitive proteasome inhibitor for Uch-L1 with IC50 of 0.88 μM, 28-fold selectivity over isoform Uch-L3.
Molecular Weight | 397.64 |
Formula | C17H11Cl3N2O3 |
CAS Number | 668467-91-2 |
Solubility (25°C) | DMSO 11 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related Deubiquitinase Products |
---|
TNG348
TNG348 is a novel, oral, potent and selective ubiquitin-specific protease 1 (USP1) inhibitor for studies related to BRCA1/2 mutations and other homologous recombination defect (HRD)+ cancers. |
FT-3171
FT-3171 is a small molecule ubiquitin-specific protease 1 (USP1) inhibitor targeting a novel DNA damage repair (DDR) pathway for studies related to solid tumors. |
BAY-728
BAY-728 serves as a negative control for BAY-805, a potent and selective USP21 inhibitor. |
BAY-805
BAY-805 is a selective inhibitor of the ubiquitin-specific protease USP21 with high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common off-target enzymes. |
USP1-IN-6
USP1-IN-6 is a USP1 inhibitor (IC50<50 nM). |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.