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LDC000067

Cat. No. M5328
LDC000067 Structure
Synonym:

LDC067

Size Price Availability Quantity
10mg USD 95 In stock
50mg USD 380 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

LDC000067 reduces Ser2-P, induces p53 activation and leads to apoptosis in mESCs. In addition, LDC067 also dose-dependently inhibits P-TEFb-dependent de novo RNA synthesis of cellular genes.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 370.43
Formula C18H18N4O3S
CAS Number 1073485-20-7
Purity >98%
Solubility 74 mg/mL in DMSO
Storage at -20°C
References

Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor.
Albert TK, et al. Br J Pharmacol. 2014 Jan;171(1):55-68. PMID: 24102143.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: LDC000067, LDC067 supplier, CDK, inhibitors

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