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Laurocapram (water soluble)

Cat. No. M9934
Laurocapram (water soluble) Structure
Size Price Availability Quantity
100mL USD 125  USD125 In stock
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Quality Control & Documentation
Biological Activity

Laurocapram is a high-efficiency skin penetration enhancer and a new type of non-ionic surfactant, has been popularized and applied in medicine, daily chemicals, pesticides, printing and dyeing, chemical fiber, leather and other industries.

Chemical Information
Molecular Weight 281.48
Formula C18H35NO
CAS Number 59227-89-3
Solubility (25°C) Soluble in water
Storage RT, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Anne Mette Handler, et al. Visualization of the penetration modifying mechanism of laurocapram by Mass Spectrometry Imaging in buccal drug delivery

[2] Miriam Lpez-Cervantes, et al. Chemical enhancers for the absorption of substances through the skin: Laurocapram and its derivatives

[3] Adrian C Williams, et al. Penetration enhancers

[4] C Szolar-Platzer, et al. Effect of topical laurocapram (Azone) on the in vitro percutaneous permeation of sodium lauryl sulfate using human skin

[5] T Ogiso, et al. Enhancement of percutaneous absorption by laurocapram

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