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Latanoprost

Cat. No. M5729

Latanoprost Structure

Synonym: Xalatan, PhXA41, PHXA-41

Size Price Availability Quantity
10mg USD 175 In stock
50mg USD 700 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Latanoprost is a prostaglandin F2alpha analogue and a prostanoid selective FP receptor agonist with an ocular hypertensive effect. Latanoprost increases uveoscleral outflow and thereby reduces intraocular pressure.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 432.59
Formula C26H40O5
CAS Number 130209-82-4
Purity >99%
Solubility 10 mM in DMSO
Storage at -20°C
References

Stability of latanoprost in generic formulations using controlled degradation and patient usage simulation studies.
Velpandian T, et al. Curr Eye Res. 2015 May;40(6):561-71. PMID: 25494824.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Latanoprost, Xalatan, PhXA41, PHXA-41 supplier, GPR, inhibitors

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