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Latanoprost

Cat. No. M5729
Latanoprost Structure
Synonym:

Xalatan, PhXA41, PHXA-41

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 160  USD160 In stock
50mg USD 480  USD480 In stock
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Quality Control & Documentation
Biological Activity

Latanoprost is a prostaglandin F2α analog as well as a prostaglandin-like selective FP receptor agonist with lipophilic and corneal penetrating properties. In addition, Latanoprost also increases ocular fluid outflow, thereby reducing intraocular pressure, and may be used in studies related to glaucoma.

Chemical Information
Molecular Weight 432.59
Formula C26H40O5
CAS Number 130209-82-4
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Velpandian T, et al. Curr Eye Res. Stability of latanoprost in generic formulations using controlled degradation and patient usage simulation studies.

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Keywords: Latanoprost, Xalatan, PhXA41, PHXA-41 supplier, Prostaglandin Receptor, inhibitors, activators


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