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Lamotrigine

Cat. No. M2802

Lamotrigine Structure
Size Price Availability Quantity
50mg USD 220 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Lamotrigine is a novel anticonvulsant compound for inhibition of 5-hydroxytryptamine (5-HT) uptake in both human platelets and rat brain synaptosomes with IC50 of 240 μM and 474 μM, respectively. Lamotrigine inhibits the synaptosomal uptake of noradrenaline and dopamine with IC50 of 239 μM and 322 μM, respectively. Lamotrigine is believed to mediate its anticonvulsant activity by the use- and voltage-dependent blockade of Na+ channels. Lamotrigine may also be useful in the treatment of bipolar illness with efficacy against depressive breakthroughs and rapid cycling bipolar disorder. The reduction in the uptake of label caused by 1 mM lamotrigine incubated in the presence of 10 nM 5-HT is reversed by increasing the substrate concentration 10-fold. The inhibition of the p-chloroamphetamine-induced 5-HT syndrome in rats suggests that lamotrigine also inhibits 5-HT uptake. Lamotrigine is a new generation broad-spectrum anticonvulsant.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 256.09
Formula C9H7Cl2N5
CAS Number 84057-84-1
Purity >99%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Lamotrigine supplier, Sodium Channel, inhibitors

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