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Lactitol

Cat. No. M10045
Lactitol Structure
Synonym:

4-β-D-galactopyranosyl-D-glucito1

Size Price Availability Quantity
25mg USD 60  USD60 In stock
50mg USD 110  USD110 In stock
100mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Lactitol is a versatile, reduced calorie sweetener derived from natural milk sugar, used in a wide variety of sweetening applications.

Chemical Information
Molecular Weight 344.31
Formula C12H24O11
CAS Number 585-86-4
Solubility (25°C) Water ≥ 100 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Kaisa Olli, et al. Front Nutr. Independent and Combined Effects of Lactitol, Polydextrose, and Bacteroides thetaiotaomicron on Postprandial Metabolism and Body Weight in Rats Fed a High-Fat Diet

[2] Lise Lotte Gluud, et al. Cochrane Database Syst Rev. Non-absorbable disaccharides versus placebo/no intervention and lactulose versus lactitol for the prevention and treatment of hepatic encephalopathy in people with cirrhosis

[3] Larry E Miller, et al. Clin Exp Gastroenterol. Efficacy and tolerance of lactitol supplementation for adult constipation: a systematic review and meta-analysis

[4] Kenji Morimoto, et al. Biosci Biotechnol Biochem. Preparation of D-gulose from disaccharide lactitol using microbial and chemical methods

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Keywords: Lactitol, 4-β-D-galactopyranosyl-D-glucito1 supplier, Antibiotic, inhibitors, activators


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