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Lacidipine is a L-type calcium channel blocker, used for treating high blood pressure.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
| Molecular Weight | 455.54 |
| Formula | C26H33NO6 |
| CAS Number | 103890-78-4 |
| Purity | >98% |
| Solubility | 91 mg/mL in DMSO |
| Storage | at -20°C |
Lacidipine attenuates TNF-α-induced cardiomyocyte apoptosis.
Wang QL, et al. Cytokine. 2015 Jan;71(1):60-5. PMID: 25226445.
| Related Calcium Channel Products |
|---|
| Dantrolene sodium salt
Inhibitor of Ca2+ release from sarcoplasmic reticulum; muscle relaxant. |
| Thapsigargin
Thapsigargin is a potent inhibitor of SERCA ATPase. |
| Mirogabalin
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium-channel complexes in the CNS. |
| Ranolazine
Ranolazine is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. |
| L-Phenylalanine
L-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. |
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