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Labetalol

Cat. No. M13893
Labetalol Structure
Synonym:

AH5158; Sch-15719W free base

Size Price Availability Quantity
100mg USD 360  USD360 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Labetalol (AH5158) is an orally active selective α1- and non-selective β-adrenergic receptors competitive antagonist. Labetalol, an anti-hypertensive agent, can be used for the research of cardiovascular disease, such as hypertension in pregnancy.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 328.41
Formula
CAS Number 36894-69-6
Purity >99%
Solubility DMSO 90 mg/mL
Storage at -20°C
References

[1] Francesco Zublena, et al. Retrospective evaluation of labetalol as antihypertensive agent in dogs

[2] Xiying Yang, et al. Distinct outcomes of labetalol exposed infants: case reports and systematic review

[3] B L Carter. Labetalol

[4] E P MacCarthy, et al. Labetalol: a review of its pharmacology, pharmacokinetics, clinical uses and adverse effects

[5] D A Richards, et al. Clinical pharmacology of labetalol

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Keywords: Labetalol, AH5158; Sch-15719W free base supplier, Adrenergic Receptor, inhibitors

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