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L-Proline

Cat. No. M9995
L-Proline Structure
Size Price Availability Quantity
25g USD 20  USD20 In stock
50g USD 30  USD30 In stock
100g USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

L-proline has been used as a component of HG-DMEM for chondrocyte differentiation and for the culture of chondrocyte-like cells. Proline is a cyclic, non-essential, hydrophobic amino acid. It is a proteinogenic amino acid which is crucial for primary metabolism. In peptide chains, proline residues confer structural constraints and enhance the susceptibility of proximal peptide bonds to protease activity.

Chemical Information
Molecular Weight 115.13
Formula C5H9NO2
CAS Number 147-85-3
Solubility (25°C) Water 50 mg/mL
Storage RT, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Vclav Pokorn, et al. Heat Capacities of l-Histidine, l-Phenylalanine, l-Proline, l-Tryptophan and l-Tyrosine

[2] Nan Li, et al. L-Proline: An Effective Agent for Frozen and Post-thawed Donkey Semen Storage

[3] Xiulai Chen, et al. Enzymatic production of trans-4-hydroxy-l-proline by proline 4-hydroxylase

[4] Xuedong Chen, et al. l-Proline protects mice challenged by Klebsiella pneumoniae bacteremia

[5] Thi Mai Hoa Bach, et al. Properties, metabolisms, and applications of (L)-proline analogues

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