Free shipping on all orders over $ 500

L-Phenylalanyl-L-leucine

Cat. No. M21608
L-Phenylalanyl-L-leucine Structure
Synonym:

H-Phe-Leu-OH

Size Price Availability Quantity
250mg USD 35  USD35 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

L-Phenylalanyl-L-leucine is a leucine derivative.

Chemical Information
Molecular Weight 278.35
Formula C15H22N2O3
CAS Number 3303-55-7
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Anders Broberg, et al. Amino Acids. In-peptide amino acid racemization via inter-residue oxazoline intermediates during acidic hydrolysis

[2] E Kessler, et al. Infect Immun. In vitro inhibition of Pseudomonas aeruginosa elastase by metal-chelating peptide derivatives

[3] A Spierer, et al. Curr Eye Res. The effect of 2-mercaptoacetyl-L-phenylalanyl-L-leucine, a specific inhibitor of Pseudomonas aeruginosa elastase, on experimental Pseudomonas keratitis in rabbit eyes

[4] S Blumberg, et al. Eur J Biochem. Inhibition of metalloendopeptidases by 2-mercaptoacetyl-dipeptides

[5] Filippova IYu, et al. Anal Biochem. L-Pyroglutamyl-L-phenylalanyl-L-leucine-p-nitroanilide--a chromogenic substrate for thiol proteinase assay

Related Products
Linderene acetate

Linderene acetate is a prolyl endopeptidase inhibitor, which can be isolated from the root of Lindera strychnifolia.

Pralmorelin

Pralmorelin (also known as KP-102, GPA-748, GHRP-2, and Growth Hormone Releasing Peptide-2) is a potent growth hormone secretagogue that acts on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone release. It acts as signal molecules that are involved in the control of cell growth and differentiation.

Methylarbutin

Methylarbutin (ß-PMP-Glc;4-Methoxyphenyl β-D-Glucopyranoside) is an ice recrystallization inhibitor (IRI).

SLK/STK10-IN-1

SLK/STK10-IN-1 is a potent and selective inhibitor of SLK and STK10 with nanomolar potency.

PP405

PP405 is a potent localized mitochondrial pyruvate carrier (MPC) inhibitor that acts on cellular metabolic pathways to up-regulate LDH and activate stem cells to promote hair growth, and can be used in studies related to androgenetic alopecia.

  Catalog
Abmole Inhibitor Catalog




Keywords: L-Phenylalanyl-L-leucine, H-Phe-Leu-OH supplier, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.