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L-NIL

Cat. No. M14099
L-NIL Structure
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Biological Activity

L-NIL is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS.

Chemical Information
Molecular Weight 187.24
CAS Number 53774-63-3
Solubility (25°C) Water 50 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] David G Leach, et al. Biomaterial-Facilitated Immunotherapy for Established Oral Cancers

[2] Aurelie Hanoteau, et al. Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy

[3] Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice

[4] Fabian Arnberg, et al. L-N-iminoethyl-lysine after experimental brain trauma attenuates cellular proliferation and astrocyte differentiation

[5] Matthieu Legrand, et al. L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats

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Keywords: L-NIL supplier, NO Synthase, inhibitors, activators


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