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KN 93

Cat. No. M6868
KN 93 Structure
Size Price Availability
1mg USD 70 Out of stock
5mg USD 135 Out of stock
10mg USD 180 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

KN 93 is a potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 μM). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC50 = 307 nM for KV1.5) and abolishes IKr in ventricular myocytes (IC50 = 102.6 nM) independently of CaM kinase II inhibition.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 501.04
Formula C26H29ClN2O4S
CAS Number 139298-40-1
Purity >98%
Solubility DMSO 50.1 mg/mL (with gentle warming)
Storage at -20°C

Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
Nolen, et al. Nature. 2009;460: 1031. PMID: 19648907.

Related CaMK Products
KN-93 hydrochloride

KN-93 hydrochloride is a cell-permeable inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK-II) with a Ki of 370 nM.

STO-609 acetate

STO-609 acetate is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ with Ki of 80 and 15 ng/ml, respectively.

KN-92 phosphate

KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93.


KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93.


A23187 is a calcium ionophore that induces Ca2+-dependent cell death by increasing intracellular calcium concentration.

Abmole Inhibitor Catalog 2017

Keywords: KN 93 supplier, CaMK, inhibitors

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