Free shipping on all orders over $ 500

KN 93

Cat. No. M6868
KN 93 Structure
Size Price Availability Quantity
1mg USD 70 In stock
5mg USD 135 In stock
10mg USD 180 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

KN 93 is a potent, cell permeable inhibitor of CaM kinase II (IC50 = 0.37 μM). Also a direct extracellular open channel blocker of voltage-gated potassium channels (IC50 = 307 nM for KV1.5) and abolishes IKr in ventricular myocytes (IC50 = 102.6 nM) independently of CaM kinase II inhibition.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 501.04
Formula C26H29ClN2O4S
CAS Number 139298-40-1
Purity >98%
Solubility DMSO 50.1 mg/mL (with gentle warming)
Storage at -20°C
References

Characterization of two classes of small molecule inhibitors of Arp2/3 complex.
Nolen, et al. Nature. 2009;460: 1031. PMID: 19648907.

Related CaMK Products
STO-609 acetate

STO-609 acetate is a cell-permeable inhibitor of calcium/calmodulin-dependent kinase kinases (CaMKK) isoforms CaMKKα and CaMKKβ with Ki of 80 and 15 ng/ml, respectively.

KN-92 phosphate

KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93.

KN-92

KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93.

KN-62

KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC50 = 900 nM).

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: KN 93 supplier, CaMK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.