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KN-93 phosphate

Cat. No. M6869
KN-93 phosphate Structure
Synonym:

CAS# 1913269-12-1

Size Price Availability Quantity
2mg USD 88  USD88 In stock
5mg USD 135  USD135 In stock
10mg USD 180  USD180 In stock
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Quality Control & Documentation
Biological Activity

KN-93 phosphate is a caM kinase II inhibitor; water soluble version of KN 93.

Chemical Information
Molecular Weight 599.03
Formula C26H29ClN2O4S.H3PO4
CAS Number 1188890-41-6
Solubility (25°C) Water 50 mg/mL
DMSO 90 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Arbitrario, et al. Cancer Chemother Pharmacol. SNS-314, a pan-Aurora kinase inhibitor, shows potent and anti-tumor activity and dosing flexibility in vivo.

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  Catalog
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Keywords: KN-93 phosphate, CAS# 1913269-12-1 supplier, CaMK, inhibitors, activators


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