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KI-7

Cat. No. M11264
KI-7  Structure
Size Price Availability Quantity
10mg USD 168  USD168 In stock
25mg USD 348  USD348 In stock
50mg USD 530  USD530 In stock
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Quality Control & Documentation
Biological Activity

Ki-7 is an A2B adenosine receptor positive allosteric regulator. Ki-7 enhances cAMP accumulation induced by NECA, a non-selective A2B adenosine receptor agonist (EC50=445.8 nM). Ki-7 also enhanced selective A2B adenosine receptor agonist BAY 60-6583 and adenosine-induced cAMP accumulation with EC50 of 2390 nM and 2550 nM, respectively.

Chemical Information
Molecular Weight 354.41
Formula C23H18N2O2
CAS Number 1489263-00-4
Solubility (25°C) DMSO ≥ 200 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Benot Bataille, et al. Med Acupunct. Japanese Acupuncture: A Complementary Approach to the Meridian Balance Method

[2] Irma Nareswari, et al. Med Acupunct. Acupuncture Therapy for Severe Oligoasthenoteratozoospermia

[3] Cong Wang, et al. Nat Sci Sleep. Impact of Acupuncture on Sleep and Comorbid Symptoms for Chronic Insomnia: A Randomized Clinical Trial

[4] Andre Benner, et al. ChemMedChem. GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists derived from 3-benzazepines: synthesis and pharmacological evaluation of benzo[7]annulen-7-amines

[5] De-Xu Chu, et al. Zhongguo Zhen Jiu. [Professor WU Lian- zhong's clinical experience for treating post-stroke distal limb dyskinesia]

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Keywords: KI-7 supplier, Adenosine Receptor, inhibitors, activators


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