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JW55

Cat. No. M2587

JW55 Structure
Size Price Availability Quantity
10mg USD 90 In stock
50mg USD 295 In stock
100mg USD 520 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

JW 55 efficacy causes stabilization of Axin2 . JW 55 also decreases canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. Inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW 55 inhibits the β-catenin signaling pathway. It Also shown to decrease canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines; JW 55 reduces cell cycle progression and proliferation in SW480 cells in vitro.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 434.48
Formula C25H26N2O5
CAS Number 664993-53-7
Purity >99%
Solubility DMSO
Storage at -20°C
References

A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.
Waaler J, et al. Cancer Res. 2012 Jun 1;72(11):2822-32. PMID: 22440753.

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BMN673 isomer

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JW55 supplier, PARP, inhibitors

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