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JQ-EZ-05

Cat. No. M7508
JQ-EZ-05 Structure
Size Price Availability
5mg USD 280 1-2 Weeks
10mg USD 475 1-2 Weeks
25mg USD 900 1-2 Weeks
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

JQ-EZ-05 is a specific and reversible EZH1/2 inhibitor.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Tumor-bearing genetically-engineered mouse models
Formulation DMSO
Dosages 75 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 542.68
Formula C30H38N8O2
CAS Number 1913252-04-6
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.
Zhang H, et al. Cancer Discov. 2016 Sep;6(9):1006-21. PMID: 27312177.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JQ-EZ-05 supplier, Histone Methyltransferase, inhibitors

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