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Josamycin

Cat. No. M19925
Josamycin Structure
Synonym:

EN-141; Kitasamycin A3; Leucomycin A3; Turimycin A5

Size Price Availability Quantity
5mg USD 95  USD95 In stock
25mg USD 240  USD240 In stock
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Quality Control & Documentation
Biological Activity

Josamycin is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.

Chemical Information
Molecular Weight 827.99
Formula C42H69NO15
CAS Number 16846-24-5
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Katsuhiko Matsui, et al. Biol Pharm Bull. Effects of Josamycin on Scratching Behavior in NC/Nga Mice with Atopic Dermatitis-Like Skin Lesions

[2] Guijun Liu, et al. J Pharm Biomed Anal. Universal response method for the quantitative analysis of multi-components in josamycin and midecamycin using liquid chromatography coupled with charged aerosol detector

[3] Eun-Young Choi, et al. Biomed Pharmacother. Josamycin suppresses Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-1β in murine macrophages

[4] X Bosch, et al. BMJ. Josamycin-induced pedal oedema

[5] No authors listed. Nihon Koku Geka Gakkai Zasshi. [Josamycin]

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  Catalog
Abmole Inhibitor Catalog




Keywords: Josamycin, EN-141; Kitasamycin A3; Leucomycin A3; Turimycin A5 supplier, Antibiotic, inhibitors, activators


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