Free shipping on all orders over $ 500


Cat. No. M1793
JNJ-38877605 Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 120 In stock
50mg USD 360 In stock
100mg USD 640 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

JNJ-38877605 is a small-molecule, ATP-competitive inhibitor of the catalytic activity of c-Met. JNJ-38877605 showed f600-fold selectivity for c-Met compared with a panel of f250 diverse tyrosine and serine-threonine kinases and was found to potently inhibit HGF-stimulated and constitutively activated c-Met phosphorylation in vitro. In addition, JNJ-38877605 induces regression of U87-MG xenografts in vivo.

Customer Product Validations & Biological Datas
Source Int J Clin Exp Med (2015). Figure 4. JNJ-38877605
Method CCK-8 assay
Cell Lines PC-3 human prostate cancer cells
Concentrations 0.125 nM, 0.5 nM, 1 nM, 2.5 nM, 5 nM, 10 nM
Incubation Time 48 h
Results However, different concentrations of saracatinib, linsitinib and JNJ-38877605 did not inhibit PC-3 cells proliferation after 48 h, high or low concentrations of the three inhibitors did not inhibit PC-3 cells proliferation at all.
Cell Experiment
Cell lines S114, GTL-16, NCI-H441, or BxPC-3 cells
Preparation method Cell Proliferation Assays. S114, GTL-16, NCI-H441, or BxPC-3 cells were seeded in 96-well plates at 9000 cells/well in medium with 10% FBS. After incubation for 48 h in low serum (0.5% FBS, S114; 0.1% FBS, GTL-16, NCI-H441, and BxPC-3), cells were treated with different concentrations of PHA-665752 for 18 h at 37°C. HGF (50 ng/ml) was added for 18 h before BrdUrd for studies involving GTL-16, H441, and BxPC-3. After incubation with BrdUrd labeling reagent for 1 h (Sigma Biochemicals, St. Louis, MO), cells were fixed and BrdUrd incorporation into newly synthesized DNA was assessed using anti-BrdUrd peroxidase-conjugated antibody followed by colorimetric determination at 630 nm.
Concentrations 0~1.25µM
Incubation time 18 h
Animal Experiment
Animal models Female athymic mice bearing S114 or GTL-16 tumor xenografts
Formulation L-lactate (pH 4.8) and 10% polyethylene glycol
Dosages 25 mg/kg a single i.v. dose
Administration via bolus i.v. tail vein injection
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 377.35
Formula C19H13F2N7
CAS Number 943540-75-8
Purity >98%
Solubility DMSO
Storage at -20°C

Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer.
De Bacco F, et al. J Natl Cancer Inst. 2011 Apr 20;103(8):645-61. PMID: 21464397.

Genetic and expression analysis of MET, MACC1, and HGF in metastatic colorectal cancer: response to met inhibition in patient xenografts and pathologic correlations.
Galimi F, et al. Clin Cancer Res. 2011 May 15;17(10):3146-56. PMID: 21447729.

Related c-Met Products

Dihexa is an orally active, blood-brain barrier-permeable angiotensin IV analog, exhibits high affinity binding hepatocyte growth factor (HGF) with a Kd of 65 pM.


NPS-1034 is a dual inhibitor of Axl and MET with IC50 values of 10.3 and 48 nM, respectively.


CEP-40783 (RXDX-106) is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively.


Savolitinib (volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase.

AMG 337

AMG 337 is an oral, small molecule, ATP-competitive, highly selective inhibitor of the MET receptor.

Abmole Inhibitor Catalog 2017

Keywords: JNJ-38877605, JNJ38877605 supplier, c-Met, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.