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JMS-17-2

Cat. No. M9653
JMS-17-2 Structure
Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 140  USD140 In stock
50mg USD 380  USD380 In stock
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Quality Control & Documentation
Biological Activity

JMS-17-2 is a potent and selective CX3CR1 antagonist with IC50 of 0.32 nM. JMS-17-2 can impairs metastatic seeding and colonization of breast cancer cells.

In vivo, JMS-17-2 (10 mg/kg; i.p.; twice a day for three weeks) causes a dramatic reduction of tumors in both skeleton and visceral organs in SCID mice.

Chemical Information
Molecular Weight 419.95
Formula C25H26ClN3O
CAS Number 1380392-05-1
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fei Shen, et al. Mol Cancer Res. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells

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Keywords: JMS-17-2 supplier, CXCR, inhibitors, activators


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