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JC-1

Cat. No. M9724
JC-1 Structure
Size Price Availability Quantity
2mg USD 100 In stock
5mg USD 190 In stock
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Quality Control
Biological Activity

JC-1 is a fluorescent lipophilic carbocyanine dye used to measure mitochondrial membrane potential.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 652.23
Formula C25H27Cl4IN4
CAS Number 3520-43-2
Purity >99%
Solubility DMSO ≥ 10 mg/mL
Storage -20°C, protect from light, dry, sealed
References

JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry
A Perelman, et al. Cell Death Dis. 2012 Nov 22;3(11):e430. PMID: 23171850.

Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria
Vera C Keil, et al. Pflugers Arch. 2011 Nov;462(5):693-708. PMID: 21881871.

Real-time analysis of amyloid fibril formation of alpha-synuclein using a fibrillation-state-specific fluorescent probe of JC-1
Jung-Ho Lee, et al. Biochem J. 2009 Mar 1;418(2):311-23. PMID: 19007333.

JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis
S Salvioli, et al. FEBS Lett. 1997 Jul 7;411(1):77-82. PMID: 9247146.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JC-1 supplier, Fluorescent Dye, inhibitors

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