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Ivabradine HCl

Cat. No. M5720
Ivabradine HCl Structure
Synonym:

S 16257-2

Size Price Availability Quantity
10mg USD 50 In stock
50mg USD 210 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 505.05
Formula C27H36N2O5.HCl
CAS Number 148849-67-6
Purity >99%
Solubility 101 mg/mL in DMSO
Storage at -20°C
References

Characterization of degradation products of ivabradine by LC-HR-MS/MS: a typical case of exhibition of different degradation behaviour in HCl and H2SO4 acid hydrolysis.
Patel PN, et al. J Mass Spectrom. 2015 Feb;50(2):344-53. PMID: 25800016.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ivabradine HCl, S 16257-2 supplier, Adrenergic Receptor, inhibitors

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