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Itacitinib adipate

Cat. No. M13853
Itacitinib adipate Structure
Size Price Availability Quantity
5mg USD 140  USD140 In stock
10mg USD 260  USD260 In stock
25mg USD 430  USD430 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 699.66
Formula
CAS Number 1334302-63-4
Purity >99%
Solubility DMSO ≥ 137.5 mg/mL
Storage 2-8°C, sealed
References

[1] Tinglei Huang, et al. Cancer Lett. Rab1A promotes IL-4R/JAK1/STAT6-dependent metastasis and determines JAK1 inhibitor sensitivity in non-small cell lung cancer

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Keywords: Itacitinib adipate supplier, JAK, inhibitors

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