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ISRIB

Cat. No. M9242
ISRIB Structure
Size Price Availability Quantity
10mg USD 230 In stock
50mg USD 690 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

ISRIB is a potent and selective PERK inhibitor with IC50 of 5 nM. ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 451.34
Formula C22H24Cl2N2O4
CAS Number 548470-11-7
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly.
Sidrauski C, et al. Elife. 2015 Feb 26;4. PMID: 25719440.

Pharmacological brake-release of mRNA translation enhances cognitive memory.
Sidrauski C, et al. Elife. 2013 May 28;2:e00498. PMID: 23741617.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: ISRIB supplier, PERK, inhibitors

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