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Isobavachalcone

Cat. No. M4844
Isobavachalcone Structure
Synonym:

Corylifolinin; Isobacachalcone

Size Price Availability Quantity
10mg USD 150 In stock
50mg USD 390 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Isobavachalcone exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Isobavachalcone hows antifungal activity.

Protocol
Cell Experiment
Cell lines E. aerogenes EA298
Preparation method The lowest MIC values for diospyrone (4 μg/ml) and isobavachalcone (8 μg/ml) were recorded for E. coli AG100A and E. aerogenes EA298, respectively.
Concentrations 8 μg/ml
Incubation time 24 h
Animal Experiment
Animal models male C57BL/6 mice
Formulation LPS
Dosages 50 and 10 mg/kg/day
Administration gavage
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 324.37
Formula C20H20O4
CAS Number 20784-50-3
Purity >98%
Solubility 11 mg/mL in DMSO
Storage at -20°C
References

Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway.
Jing H, et al. PLoS One. 2017 Jan 6;12(1):e0169560. PMID: 28060896.

Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells.
Ohno O, et al. Biosci Biotechnol Biochem. 2010;74(7):1504-6. PMID: 20622433.

Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
Kuete V, et al. Antimicrob Agents Chemother. 2010 May;54(5):1749-52. PMID: 20160051.

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Keywords: Isobavachalcone, Corylifolinin; Isobacachalcone supplier, Autophagy, inhibitors

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