Inhibitor of Epstein-Barr virus early antigen (EBV-EA) induction. Isobavachalcone exhibits potent inhibitory effect on skin tumor promotion. Potent inhibitor of MMP-2. Displays DNA strand-scission (cleaving) activity. Isobavachalcone hows antifungal activity.
|Cell lines||E. aerogenes EA298|
|Preparation method||The lowest MIC values for diospyrone (4 μg/ml) and isobavachalcone (8 μg/ml) were recorded for E. coli AG100A and E. aerogenes EA298, respectively.|
|Incubation time||24 h|
|Animal models||male C57BL/6 mice|
|Dosages||50 and 10 mg/kg/day|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||11 mg/mL in DMSO|
Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway.
Jing H, et al. PLoS One. 2017 Jan 6;12(1):e0169560. PMID: 28060896.
Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells.
Ohno O, et al. Biosci Biotechnol Biochem. 2010;74(7):1504-6. PMID: 20622433.
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
Kuete V, et al. Antimicrob Agents Chemother. 2010 May;54(5):1749-52. PMID: 20160051.
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