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Iron dextran

Cat. No. M9859
Iron dextran Structure
Synonym:

Fe dextran

Size Price Availability Quantity
25g USD 120  USD120 In stock
100g USD 300  USD300 In stock
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Quality Control & Documentation
Biological Activity

Iron dextran (Fe dextran) is used in the study of iron-deficiency anemia.

Chemical Information
Molecular Weight 153.92
Formula FeH2O4S
CAS Number 9004-66-4
Solubility (25°C) Water
Storage RT
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wanting Shu, et al. Invest Ophthalmol Vis Sci. Iron Accumulates in Retinal Vascular Endothelial Cells But Has Minimal Retinal Penetration After IP Iron Dextran Injection in Mice

[2] Natacha E Piloni, et al. Toxicology. Acute iron overload and oxidative stress in brain

[3] Priya Prakash Karmali, et al. Mol Pharm. Different effect of hydrogelation on antifouling and circulation properties of dextran-iron oxide nanoparticles

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Keywords: Iron dextran, Fe dextran supplier, inhibitors, activators


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