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IRAK-1-4 Inhibitor I

Cat. No. M9340
IRAK-1-4 Inhibitor I Structure
Size Price Availability Quantity
5mg USD 100  USD100 In stock
10mg USD 140  USD140 In stock
25mg USD 275  USD275 In stock
50mg USD 480  USD480 In stock
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Quality Control & Documentation
Biological Activity

IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor-associated kinase 1/4 (IRAK 1/4) with IC50s of 0.3 μM and 0.2 μM, respectively. IRAK-1/4 inhibitor eliminates the LPS-induced increases in Bcl10, NF-κB, and IL-8. IRAK-1/4 mediates LPS-induced IL-8 activation and functions upstream of Bcl10.

Chemical Information
Molecular Weight 395.41
Formula C20H21N5O4
CAS Number 509093-47-4
Solubility (25°C) DMSO ≥ 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Bhattacharyya S, et al. Am J Physiol Gastrointest Liver Physiol. Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells.

[2] Powers JP, et al. Bioorg Med Chem Lett. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

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  Catalog
Abmole Inhibitor Catalog




Keywords: IRAK-1-4 Inhibitor I supplier, IRAK, inhibitors, activators


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