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IFNγ, Human(CHO-expressed)

Cat. No. M9240
IFNγ, Human(CHO-expressed) Structure
Synonym:

Interferon gamma, Immune Interferon, type II interferon

Size Price Availability Quantity
10ug USD 120 In stock
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Quality Control
  • Current batch:
  • Purity >95%
  • COA
  • MSDS
Biological Activity

IFNγ is a cytokine that is critical for innate and adaptive immunity against viral, some bacterial and protozoal infections. IFNγ is an important activator of macrophages and inducer of Class II major histocompatibility complex (MHC) molecule expression. Aberrant IFNγ expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNγ in the immune system stems in part from its ability to inhibit viral replication directly, and most importantly from its immunostimulatory and immunomodulatory effects. IFNγ is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 Th1 and CD8 cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops. ED50 < 2 ng/ml, measured in a cytotoxicity assay using HT-29 cells, corresponding to a specific activity of > 5×105 units/mg.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 17145.36
Formula C761H1206N214O225S6
CAS Number 98059-61-1
Purity >95%
Solubility in ddH2O or PBS at 100 μg/ml
Storage at -20°C
References

Genetic polymorphisms in the promoter of the interferon gamma receptor 1 gene are associated with atopic cataracts.
Matsuda A, et al. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):583-9. PMID: 17251453.

FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin.
Park-Min KH, et al. Immunity. 2007 Jan;26(1):67-78. PMID: 17239631.

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Keywords: IFNγ, Human(CHO-expressed), Interferon gamma, Immune Interferon, type II interferon supplier, inhibitors

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