Ingenol mebutate gel applied topically for 2 to 3 days is effective for field treatment of actinic keratoses.Ingenol mebutate is a Cell Death Inducer. The physiologic effect of ingenol mebutate is by means of Increased Cellular Death.
|Cell lines||T7 cell|
|Preparation method||Tumours were treated topically (on days 4 and 5 post tumour inoculation) with 30 μl of 0.25 % (w/v) ingenol mebutate or placebo gel (supplied by LEO Pharma A/S) using a positive displacement pipette, with the gel then spread over the tumour site.|
|Concentrations||30 μl of 0.25 % (w/v)|
|Incubation time||48 h|
|Animal models||BALB/c nu−/nu− mice|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||41 mg/ml in CHCl3|
Effective treatment of squamous cell carcinomas with ingenol mebutate gel in immunologically intact SKH1 mice.
Cozzi SJ, et al. Arch Dermatol Res. 2013 Jan;305(1):79-83. PMID: 22871992.
Ingenol mebutate gel for actinic keratosis.
Lebwohl M,et.al. N Engl J Med. 2012 Mar 15;1010-9. PMID: 22417254.
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