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Indolicidin

Cat. No. M10574
Indolicidin Structure
Synonym:

ILPWKWPWWPWRR-NH2

Size Price Availability
1mg USD 318  USD318 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Indolicidin is a potent antimicrobial peptide purified from the cytoplasmic granules of bovine neutrophils. Indolicidin is comprised of 13 amino acids, 5 of which are tryptophan residues, and the carboxylterminal arginine is carboxamidated. Indolicidin binds purified surface lipopolysaccharide with high affinity and permeabilized the outer membrane of Escherichia coli to the small hydrophobic molecule 1-N-phenylnapthylamine (Mr 200), results consistent with indolicidin crossing the outer membrane via the self-promoted uptake pathway.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 1906.28
Formula C100H132N26O13
CAS Number 140896-21-5
Purity >99%
Solubility Water 1 mg/mL
Storage -20°C, protect from light, sealed
References

[1] T J Falla, et al. J Biol Chem. Mode of action of the antimicrobial peptide indolicidin

[2] M E Selsted, et al. J Biol Chem. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils

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