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INCB3284 dimesylate

Cat. No. M6263
INCB3284 dimesylate Structure
Size Price Availability
10mg USD 200 Custom Synthesis
50mg USD 675 Custom Synthesis
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

INCB 3284 dimesylate exhibits potenct antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). INCB 3284 also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μM).

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models male C57Bl/6 mice
Formulation
Dosages 1 mg/kg/day
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 712.76
Formula C28H39F3N4O10S2
CAS Number 887401-93-6
Purity >98%
Solubility 10 mM in DMSO
Storage at -20°C
References

Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline
McMillin M, et al. J Neuroinflammation. 2014 Jul 10;11:121. PMID: 25012628.

Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation.
Zhou X, et al. J Am Soc Nephrol. 2015 Jan;26(1):121-32. PMID: 24904083.

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  Catalog
Abmole Inhibitor Catalog 2017




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