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Ifenprodil Tartrate

Cat. No. M2767
Ifenprodil Tartrate Structure
Size Price Availability Quantity
50mg USD 75 In stock
100mg USD 120 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ifenprodil is an atypical noncompetitive antagonist at the NMDA receptor, it interacts with high affinity at a homogeneous population of NMDA receptors in neonatal rat forebrain with IC50 of 0.3 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 475.53
Formula C21H27NO2.1/2C4H6O6
CAS Number 23210-58-4
Purity >99%
Solubility DMSO 80 mg/mL
Storage at -20°C
Customer Product Validations & Biological Datas
Source Discov Med (2017). Figure 5. Ifenprodil (Abmole Bioscience, Houston, TX)
Method Western blot
Cell Lines Sprague-Dawley rats
Concentrations 1 mg/kg
Incubation Time 24 h
Results PTZ-kindled rats had increased level of Cdk5 in white matters, memantine, ifenprodil, lithium chloride (LiCl), and roscovitine decreased Cdk5 in PTZ-kindled rats.
Rating
Source Discov Med (2017). Figure 4. Ifenprodil (Abmole Bioscience, Houston, TX)
Method Immunohistochemistry
Cell Lines Sprague-Dawley rats
Concentrations 1 mg/kg
Incubation Time 24 h
Results Representative immunohistochemical microphotographs showed increased accumulation of APP in corpus callosum in PTZ-kindled rats. Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated the accumulation.
Rating
Source Discov Med (2017). Figure 3. Ifenprodil (Abmole Bioscience, Houston, TX)
Method Immunohistochemistry
Cell Lines Sprague-Dawley rats
Concentrations 1 mg/kg
Incubation Time 24 h
Results Memantine, ifenprodil, lithium chloride (LiCl), and roscovitine alleviated such reduction.
Rating
Source Discov Med (2017). Figure 2. Ifenprodil (Abmole Bioscience, Houston, TX)
Method Western Blot
Cell Lines Sprague-Dawley rats
Concentrations 1 mg/kg
Incubation Time 24 h
Results Memantine, ifenprodil, and LiCl increased tau in PTZ-kindled rats and decreased relative tau phosphorylation level, but failed to decrease p-tau S396 and p-tau T231.
Rating
Product Citations
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ifenprodil Tartrate supplier, GluR, inhibitors

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