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Idasanutlin (RG-7388)

Cat. No. M5700
Idasanutlin (RG-7388) Structure
Synonym:

Idasanutlin

Size Price Availability Quantity
5mg USD 130 In stock
10mg USD 180 In stock
50mg USD 500 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 616.48
Formula C31H29Cl2F2N3O4
CAS Number 1229705-06-9
Purity >98%
Solubility 100 mg/mL in DMSO
Storage at -20°C
References

Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia models.
Lehmann C, et al. J Hematol Oncol. 2016 Jun 28;9(1):50. PMID: 27353420.

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  Catalog
Abmole Inhibitor Catalog 2017




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