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Ibutilide fumarate

Cat. No. M5699
Ibutilide fumarate Structure
Synonym:

U-70226E

Size Price Availability Quantity
10mg USD 60 In stock
100mg USD 200 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 885.23
Formula (C20H36N2O3S)2.C4H4O4
CAS Number 122647-32-9
Purity >99%
Solubility 89 mg/mL in DMSO
Storage at -20°C
References

Efficacy and safety of ibutilide for chemical cardioversion of atrial fibrillation and atrial flutter in cancer patients.
Bickford CL, et al. Am J Med Sci. 2014 Apr;347(4):277-81. PMID: 23588261.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ibutilide fumarate, U-70226E supplier, Sodium Channel, inhibitors

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