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Hydroxychloroquine Sulfate

Cat. No. M5159
Hydroxychloroquine Sulfate Structure
Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 60 In stock
50mg USD 180 In stock
100mg USD 260 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Hydroxychloroquine Sulfate is an inhibitor of autophagy and toll-like receptor (TLR) 7/9. Hydroxychloroquine Sulfate is used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 433.95
Formula C18H28ClN3O5S
CAS Number 747-36-4
Purity >98%
Solubility Water 60 mg/mL
Storage at -20°C
References

Hydroxychloroquine modulates metabolic activity and proliferation and induces autophagic cell death of human dermal fibroblasts.
Ramser B, et al. J Invest Dermatol. 2009 Oct;129(10):2419-26. PMID: 19357706.

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Abmole Inhibitor Catalog 2017




Keywords: Hydroxychloroquine Sulfate supplier, Autophagy, inhibitors

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