Free shipping on all orders over $ 500

Hydroxychloroquine Sulfate

Cat. No. M5159

Hydroxychloroquine Sulfate Structure
Size Price Availability Quantity
10mg USD 95 In stock
50mg USD 180 In stock
100mg USD 260 In stock
Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Hydroxychloroquine Sulfate is an inhibitor of autophagy and toll-like receptor (TLR) 7/9. Hydroxychloroquine Sulfate is used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 433.95
Formula C18H28ClN3O5S
CAS Number 747-36-4
Purity >99%
Solubility Water 60 mg/mL
Storage at -20°C
References

Hydroxychloroquine modulates metabolic activity and proliferation and induces autophagic cell death of human dermal fibroblasts.
Ramser B, et al. J Invest Dermatol. 2009 Oct;129(10):2419-26. PMID: 19357706.

Related Autophagy Products
Corynoxine

Corynoxine is an enantiomer of Corynoxine B; induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.

SBI-0206965

SBI-0206965 is a potent, selective and cell permeable autophagy kinase ULK1 inhibitor with IC50 of 108 nM for ULK1 kinase activity and 711 nM for the highly related kinase ULK2 .

Flubendazole

Flubendazole is an autophagy inducer by targeting Atg4B, used to treat internal parasite and worm infection.

Azithromycin

Azithromycin is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

Spautin-1

Spautin-1 is a potent and specific autophagy inhibitor, and inhibits the deubiquitinating activity of USP10 and USP13 with IC50 of ∼0.6-0.7 μM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Hydroxychloroquine Sulfate supplier, Autophagy, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.