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HUHS015

Cat. No. M9246
HUHS015 Structure
Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 100 In stock
50mg USD 290 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

HUHS015 is a potent PCA-1/ALKBH3 inhibitor both in vitro and in vivo. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. As expected, continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 318.37
Formula C19H18N4O
CAS Number 1453097-13-6
Purity >99%
Solubility DMSO: ≥ 25 mg/mL
Storage at -20°C
References

Design and synthesis of prostate cancer antigen-1 (PCA-1/ALKBH3) inhibitors as anti-prostate cancer dru gs.
Nakao S, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1071-4. PMID: 24461353.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: HUHS015 supplier, inhibitors

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